Trace metal quantification in bladder biopsies from tumoral lesions of Tunisian cancer and controls subjects.
Identifieur interne : 000060 ( Main/Exploration ); précédent : 000059; suivant : 000061Trace metal quantification in bladder biopsies from tumoral lesions of Tunisian cancer and controls subjects.
Auteurs : Molka Feki-Tounsi [France] ; Pablo Olmedo ; Fernando Gil ; Mohamed-Nabil Mhiri ; Ahmed Rebai ; Amel Hamza-ChaffaiSource :
- Environmental science and pollution research international [ 1614-7499 ] ; 2014.
Descripteurs français
- Wicri :
- geographic : Tunisie.
English descriptors
- KwdEn :
- Aged, Arsenic (analysis), Biopsy, Cadmium (analysis), Case-Control Studies, Chromium (analysis), Environmental Monitoring, Environmental Pollutants (analysis), Female, Humans, Middle Aged, Nickel (analysis), Spectrophotometry, Atomic, Tunisia (epidemiology), Urinary Bladder (chemistry), Urinary Bladder (pathology), Urinary Bladder Neoplasms (chemistry), Urinary Bladder Neoplasms (pathology).
- MESH :
- chemical , analysis : Arsenic, Cadmium, Chromium, Environmental Pollutants, Nickel.
- geographic , epidemiology : Tunisia.
- chemistry : Urinary Bladder, Urinary Bladder Neoplasms.
- pathology : Urinary Bladder, Urinary Bladder Neoplasms.
- Aged, Biopsy, Case-Control Studies, Environmental Monitoring, Female, Humans, Middle Aged, Spectrophotometry, Atomic.
Abstract
The incidence of bladder tumors has been dramatically increasing since the 1970s, possibly as a consequence of ongoing environmental pollution. Previous studies have provided some evidence of an association between cancer and exposure to carcinogenic metals. In order to examine the association between levels of toxic metals in patients with bladder tumors and controls, the amounts of arsenic, cadmium, chromium, and nickel were measured in tumoral lesions and adjacent normal part of the bladder mucosa excised for carcinoma and compared with those in the bladder mucosa of volunteer subjects operated for non-neoplastic diseases. The quantification of metals in tissue was assessed by atomic absorption spectroscopy. In tumoral tissues of the excised bladder mucosa, content of Cr and Ni was significantly low compared to that of adjacent normal tissues and control tissues while that of As and Cd in normal tissues adjacent to the tumor were significantly elevated compared to controls. Though the sample size was small, the present study shows that concentrations of metals such as Cd, Cr, As, and Ni in bladder tissue may be used as a biomarker of exposure. On the basis of the results obtained in this study, high amounts of As and Cd in adjacent normal parts of the bladders with carcinomas compared to controls would strongly suggest possible, individual or synergistic, effects of these pollutants on enzymatic systems, priming an oncogenic pathway.
DOI: 10.1007/s11356-014-3099-x
PubMed: 24903250
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000043
- to stream PubMed, to step Curation: 000043
- to stream PubMed, to step Checkpoint: 000043
- to stream Ncbi, to step Merge: 000109
- to stream Ncbi, to step Curation: 000109
- to stream Ncbi, to step Checkpoint: 000109
- to stream Main, to step Merge: 000060
- to stream Main, to step Curation: 000060
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Trace metal quantification in bladder biopsies from tumoral lesions of Tunisian cancer and controls subjects.</title><author><name sortKey="Feki Tounsi, Molka" sort="Feki Tounsi, Molka" uniqKey="Feki Tounsi M" first="Molka" last="Feki-Tounsi">Molka Feki-Tounsi</name><affiliation wicri:level="1"><nlm:affiliation>Unit of Marine and Environmental Toxicology, IPEIS, Sfax University, PB 805, 3018, Sfax, Tunisia, molkafekitounsi@yahoo.fr.</nlm:affiliation><country wicri:rule="url">France</country><wicri:regionArea>Unit of Marine and Environmental Toxicology, IPEIS, Sfax University, PB 805, 3018, Sfax, Tunisia</wicri:regionArea><wicri:noRegion>Tunisia</wicri:noRegion><wicri:noRegion>Tunisia</wicri:noRegion></affiliation></author><author><name sortKey="Olmedo, Pablo" sort="Olmedo, Pablo" uniqKey="Olmedo P" first="Pablo" last="Olmedo">Pablo Olmedo</name></author><author><name sortKey="Gil, Fernando" sort="Gil, Fernando" uniqKey="Gil F" first="Fernando" last="Gil">Fernando Gil</name></author><author><name sortKey="Mhiri, Mohamed Nabil" sort="Mhiri, Mohamed Nabil" uniqKey="Mhiri M" first="Mohamed-Nabil" last="Mhiri">Mohamed-Nabil Mhiri</name></author><author><name sortKey="Rebai, Ahmed" sort="Rebai, Ahmed" uniqKey="Rebai A" first="Ahmed" last="Rebai">Ahmed Rebai</name></author><author><name sortKey="Hamza Chaffai, Amel" sort="Hamza Chaffai, Amel" uniqKey="Hamza Chaffai A" first="Amel" last="Hamza-Chaffai">Amel Hamza-Chaffai</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24903250</idno><idno type="pmid">24903250</idno><idno type="doi">10.1007/s11356-014-3099-x</idno><idno type="wicri:Area/PubMed/Corpus">000043</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000043</idno><idno type="wicri:Area/PubMed/Curation">000043</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000043</idno><idno type="wicri:Area/PubMed/Checkpoint">000043</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000043</idno><idno type="wicri:Area/Ncbi/Merge">000109</idno><idno type="wicri:Area/Ncbi/Curation">000109</idno><idno type="wicri:Area/Ncbi/Checkpoint">000109</idno><idno type="wicri:Area/Main/Merge">000060</idno><idno type="wicri:Area/Main/Curation">000060</idno><idno type="wicri:Area/Main/Exploration">000060</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Trace metal quantification in bladder biopsies from tumoral lesions of Tunisian cancer and controls subjects.</title><author><name sortKey="Feki Tounsi, Molka" sort="Feki Tounsi, Molka" uniqKey="Feki Tounsi M" first="Molka" last="Feki-Tounsi">Molka Feki-Tounsi</name><affiliation wicri:level="1"><nlm:affiliation>Unit of Marine and Environmental Toxicology, IPEIS, Sfax University, PB 805, 3018, Sfax, Tunisia, molkafekitounsi@yahoo.fr.</nlm:affiliation><country wicri:rule="url">France</country><wicri:regionArea>Unit of Marine and Environmental Toxicology, IPEIS, Sfax University, PB 805, 3018, Sfax, Tunisia</wicri:regionArea><wicri:noRegion>Tunisia</wicri:noRegion><wicri:noRegion>Tunisia</wicri:noRegion></affiliation></author><author><name sortKey="Olmedo, Pablo" sort="Olmedo, Pablo" uniqKey="Olmedo P" first="Pablo" last="Olmedo">Pablo Olmedo</name></author><author><name sortKey="Gil, Fernando" sort="Gil, Fernando" uniqKey="Gil F" first="Fernando" last="Gil">Fernando Gil</name></author><author><name sortKey="Mhiri, Mohamed Nabil" sort="Mhiri, Mohamed Nabil" uniqKey="Mhiri M" first="Mohamed-Nabil" last="Mhiri">Mohamed-Nabil Mhiri</name></author><author><name sortKey="Rebai, Ahmed" sort="Rebai, Ahmed" uniqKey="Rebai A" first="Ahmed" last="Rebai">Ahmed Rebai</name></author><author><name sortKey="Hamza Chaffai, Amel" sort="Hamza Chaffai, Amel" uniqKey="Hamza Chaffai A" first="Amel" last="Hamza-Chaffai">Amel Hamza-Chaffai</name></author></analytic><series><title level="j">Environmental science and pollution research international</title><idno type="eISSN">1614-7499</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Arsenic (analysis)</term><term>Biopsy</term><term>Cadmium (analysis)</term><term>Case-Control Studies</term><term>Chromium (analysis)</term><term>Environmental Monitoring</term><term>Environmental Pollutants (analysis)</term><term>Female</term><term>Humans</term><term>Middle Aged</term><term>Nickel (analysis)</term><term>Spectrophotometry, Atomic</term><term>Tunisia (epidemiology)</term><term>Urinary Bladder (chemistry)</term><term>Urinary Bladder (pathology)</term><term>Urinary Bladder Neoplasms (chemistry)</term><term>Urinary Bladder Neoplasms (pathology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Arsenic</term><term>Cadmium</term><term>Chromium</term><term>Environmental Pollutants</term><term>Nickel</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Tunisia</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Urinary Bladder</term><term>Urinary Bladder Neoplasms</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Urinary Bladder</term><term>Urinary Bladder Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Biopsy</term><term>Case-Control Studies</term><term>Environmental Monitoring</term><term>Female</term><term>Humans</term><term>Middle Aged</term><term>Spectrophotometry, Atomic</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Tunisie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The incidence of bladder tumors has been dramatically increasing since the 1970s, possibly as a consequence of ongoing environmental pollution. Previous studies have provided some evidence of an association between cancer and exposure to carcinogenic metals. In order to examine the association between levels of toxic metals in patients with bladder tumors and controls, the amounts of arsenic, cadmium, chromium, and nickel were measured in tumoral lesions and adjacent normal part of the bladder mucosa excised for carcinoma and compared with those in the bladder mucosa of volunteer subjects operated for non-neoplastic diseases. The quantification of metals in tissue was assessed by atomic absorption spectroscopy. In tumoral tissues of the excised bladder mucosa, content of Cr and Ni was significantly low compared to that of adjacent normal tissues and control tissues while that of As and Cd in normal tissues adjacent to the tumor were significantly elevated compared to controls. Though the sample size was small, the present study shows that concentrations of metals such as Cd, Cr, As, and Ni in bladder tissue may be used as a biomarker of exposure. On the basis of the results obtained in this study, high amounts of As and Cd in adjacent normal parts of the bladders with carcinomas compared to controls would strongly suggest possible, individual or synergistic, effects of these pollutants on enzymatic systems, priming an oncogenic pathway.</div></front></TEI><affiliations><list><country><li>France</li></country></list><tree><noCountry><name sortKey="Gil, Fernando" sort="Gil, Fernando" uniqKey="Gil F" first="Fernando" last="Gil">Fernando Gil</name><name sortKey="Hamza Chaffai, Amel" sort="Hamza Chaffai, Amel" uniqKey="Hamza Chaffai A" first="Amel" last="Hamza-Chaffai">Amel Hamza-Chaffai</name><name sortKey="Mhiri, Mohamed Nabil" sort="Mhiri, Mohamed Nabil" uniqKey="Mhiri M" first="Mohamed-Nabil" last="Mhiri">Mohamed-Nabil Mhiri</name><name sortKey="Olmedo, Pablo" sort="Olmedo, Pablo" uniqKey="Olmedo P" first="Pablo" last="Olmedo">Pablo Olmedo</name><name sortKey="Rebai, Ahmed" sort="Rebai, Ahmed" uniqKey="Rebai A" first="Ahmed" last="Rebai">Ahmed Rebai</name></noCountry><country name="France"><noRegion><name sortKey="Feki Tounsi, Molka" sort="Feki Tounsi, Molka" uniqKey="Feki Tounsi M" first="Molka" last="Feki-Tounsi">Molka Feki-Tounsi</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Terre/explor/NickelMaghrebV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000060 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000060 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Terre
|area= NickelMaghrebV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:24903250
|texte= Trace metal quantification in bladder biopsies from tumoral lesions of Tunisian cancer and controls subjects.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:24903250" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a NickelMaghrebV1
| This area was generated with Dilib version V0.6.27. |  |